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Urethral Syndrome

About

  • Condition that affects the urethra (the tube that carries urine from the bladder to outside the body)
  • Inflamed/irritated urethra
  • Most common in women

Potential Causes

  • Physical problems with the urethra such as abnormal narrowing, urethral irritation or injury
  • The urethra can be irritated by:
    • Scented products (perfumes, soaps, bubble bath and sanitary napkins)
    • Spermicidal jellies
    • Certain foods and drinks containing caffeine
    • Chemotherapy and radiation
  • The urethra can be injured by:
    • Sexual activity
    • Diaphragm use
    • Tampon use
    • Bike riding
  • Increased risk of developing urethral syndrome if you:
    • Are prone to bacterial bladder/kidney infections
    • Take certain medications
    • Have sex without a condom
    • Have an STI

Symptoms

  • Pain with urination
  • Lower abdominal pain/pressure
  • Urinary urgency
  • Urinary frequency
  • Urinary difficulty
  • Pain during sex
  • Blood in the urine
  • Bladder not feeling empty after urinating
  • Swelling of the testicles (men)
  • Pain while ejaculating (men)
  • Blood in the semen/urine (men)
  • Discomfort in the vulvar area (women)

Diagnosis

  • Medical history review and symptom evaluation
  • Physical exam including the genitals, abdomen and rectum
  • Urine sample: To rule out bacterial infection
  • Urethroscopy: To see the inside of the urethra
  • Pelvic ultrasound

Treatment

  • Lifestyle changes: Refrain from using products, eating/drinking food and beverages or doing activities that can irritate the urethra
  • Medications
    • Anesthetics: Phenazopyridine, Lidocaine 
    • Antispasmodics: Hyoscyamine, Oxybutynin
    • Tricyclic Antidepressants: Amitriptyline, Nortriptyline
      • Act on your nerves to help relieve chronic pain
  • Alpha-blockers: Doxazosin, Prazosin
    • Improve blood flow by relaxing the muscles in your blood vessels
  • Dilation/Surgery: To widen your urethra if the syndrome is due to constriction